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Awesome write-up. Do you have a sense for where antibody design is relative to TCR-epitope binding prediction? I spoke with Felix Drost last summer about his work benchmarking those algorithms, and he seemed to think the results were very poor for new epitopes. Tweetorial and preprint:

https://x.com/DrostFelix/status/1855887293451559247

https://www.biorxiv.org/content/10.1101/2024.11.06.622261v1

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