Abhishaike, your essays are such a delight to read. I appreciate the effort that clearly goes into putting them together. Each one is like visiting the best poster at a conference, where you come away infused with passion for a topic you’d never really thought about before. Thank you!!
We showcase PANCS-Binders by screening multiple protein libraries each against a panel of 95 separate targets, thereby individually assessing more than 10power11 protein–protein interaction pairs, in 2 days. These selections yielded large, high-quality datasets and hundreds of novel binders, which can be affinity matured or directly used in mammalian cells to inhibit or degrade targets. This kind of directed evolution is reminiscent of https://en.wikipedia.org/wiki/Systematic_evolution_of_ligands_by_exponential_enrichment
Abhishaike, your essays are such a delight to read. I appreciate the effort that clearly goes into putting them together. Each one is like visiting the best poster at a conference, where you come away infused with passion for a topic you’d never really thought about before. Thank you!!
what a kind comment, thank you so much :) happy it is enjoyable!
I second that.
Interesting and informative - thank you!
Excellent post, see also https://www.nature.com/articles/s41592-025-02781-5 which test the effect of 13,221 drugs on 3,407 genes
also the best db I know to find ligands for a receptor is https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1075232#LigandEfficiencies
do you know alternatives?
another impressive advance seems to be https://www.nature.com/articles/s41592-025-02740-0
We showcase PANCS-Binders by screening multiple protein libraries each against a panel of 95 separate targets, thereby individually assessing more than 10power11 protein–protein interaction pairs, in 2 days. These selections yielded large, high-quality datasets and hundreds of novel binders, which can be affinity matured or directly used in mammalian cells to inhibit or degrade targets. This kind of directed evolution is reminiscent of https://en.wikipedia.org/wiki/Systematic_evolution_of_ligands_by_exponential_enrichment
https://www.nature.com/articles/s41586-025-09248-9