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Corin Wagen's avatar

Nice post - learned a lot.

re: microbiome + therapeutics, I like this finding: https://www.science.org/doi/10.1126/science.aau6323. Thinking about microbiome effects on drug metabolism for already understood drugs seems more actionable to me, at least in the short term.

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Metacelsus's avatar

Regarding the cancer microbiome controversy, I am on the side of the skeptics. The issue of mis-identifying human sequences as bacterial (due to human DNA contamination in bacterial reference genomes) is a big problem, and the authors of the original study didn't properly filter out human-derived sequencing reads. That error, by itself, invalidates the paper.

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